An Introduction to Transforming Growth Factor Beta 1 or TGFβ-1


    In 1957, Alick Isaacs and Jean Lindenmann first described IFNs as a viral replication interfering agent. Type I IFN family has 13 α subtypes, out of which IFNα 2 was the very first subtypes scientists had successfully characterized in the 1980s. Therefore, researchers have widely studied IFNα 2 and the alpha interferon function to understand type I IFN family structure and mechanisms. As a result, the pharmaceutical industry also produced IFNα 2 as the first IFN drug, making it a well-known type I IFN family subtype.

    Alpha interferon function, also referred to as IFNA2 or FNA2, was measured using our alpha interferon test, which measures the presence of alpha interferon in blood. The Alpha interferon test can be used to monitor the success of therapy by measuring intra-cellular levels of alpha interferon. More research on the function of IFNα 2 is being conducted globally and scientists are continuing efforts to understand its role in viral infection.

    Alpha Interferon function is one of the best biomarkers available for survival analysis in patients with lung cancer. IFNα 2 is produced in the body to help fight viral infections and a variety of other harmful conditions, including autoimmune diseases and cancers. The higher the level of Alpha Interferon function present in a patient’s blood, the better his or her prognosis.

    Transformation growth factor beta 1 or TGFbeta1 (also known as TGFB1) is a human polypeptide encoded by the TGFB1 gene. This gene is on the q arm of chromosome 19. The TGFB1 gene encodes a transmembrane protein that belongs to the transforming growth factor beta superfamily. The mature form of the protein is secreted from bone tissue onto the surface of bone-derived cells, and mediates osteoclast formation in bone. TGFB1 regulates several cellular functions, including cell proliferation, cell growth, cell differentiation, cell motility, and apoptosis. It has recently been recognized as having a number of functions in cancer. In non-cancer settings it has been implicated in regulating colorectal cancer dedifferentiation and carcinogenesis, cerebral cortical development and morphogenesis, liver regeneration and hepatocellular carcinoma (HCC), pancreatic duct development in congenital nephrogenic diabetes insipidus (CDI), retinal wound healing and angiogenesis. 

    Transforming growth factor beta 1 or TGFβ-1, also known as Epithelial cell-derived growth factor (EDGF), is a polypeptide encoded by the gene TGFB1. This gene encodes for a protein that belongs to the transforming growth factor beta superfamily. Since its discovery in the early 1980s and subsequent characterization of its multiple biological functions, TGFβ1 has become known for its many roles in wound healing and bone formation. This protein is present throughout the body, but its concentrations are especially high in bone and cartilage tissues, where it plays an important role in their formation and maintenance. This peptide has been shown to increase the formation of chondrocytes, osteoblasts and osteoclasts; this is mediated by increasing fibroblast proliferation and inhibiting matrix synthesis. Mature TGFβ1 binds to type 1 transmembrane transducer and activator of transcription (Tat) on pre-mRNA, producing a functional protein that will bind to Smad proteins and initiate protein synthesis. Through this process, TGFβ1 does not need to be activated by proteolytic cleavage from the precursor protein.

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